In-Depth Knowledge

Everything we know about propolis, in one place.

What propolis is, what it is made of, where ours comes from, and honest answers to the questions we hear most often — from the apiary to the extract.

Family apiary on the hills of southeastern Brazil at golden hour, beekeepers walking between the hives
Our apiary on the hills near the Tropic of Capricorn, southeastern Brazil.

The basics

Introduction

Propolis is a resin that honeybees make from buds, bark and sap of specific plants. Bees blend these plant resins with their own enzymes and beeswax and use the mixture to seal cracks in the hive, smooth its inner walls and keep the colony environment clean — which is why propolis is often called the hive's protective resin.

People have collected and used propolis for thousands of years, and today it is one of the most studied bee products. Modern research focuses on its antioxidant compounds and on how it supports the body's natural defenses.

Beekeeper scraping raw green propolis from a hive frame
Raw propolis being scraped from a hive frame.

What is inside

Composition and Properties

Propolis — whether "green propolis" or "red propolis" — is a complex mix of resins, balsams, essential oils, beeswax and a little pollen. Researchers have identified more than 300 compounds in propolis, and the list keeps growing: flavonoids, phenolic acids such as caffeic and p-coumaric acid, prenylated compounds, terpenes and small amounts of vitamins and minerals.

These compounds are the reason propolis is valued as a dietary supplement. They support the body's antioxidant defenses, help the body manage oxidative stress and support immune health. The exact profile depends on the plants the bees visited, which is why origin matters so much.

Chunks of raw green propolis beside a sprig of Baccharis dracunculifolia
Raw green propolis beside a sprig of Baccharis dracunculifolia.

Where it starts

Where it starts defines its quality

Brazilian green propolis comes from Baccharis dracunculifolia, the alecrim-do-campo shrub native to southeastern Brazil. Its signature compound is artepillin C, a prenylated phenolic that serves as the marker of authentic green propolis, alongside related compounds such as baccharin.

Brazilian red propolis comes from the resin of Dalbergia ecastaphyllum, which grows in the mangroves along the coast of northeastern Brazil. It is rich in isoflavonoids such as formononetin and vestitol, which give it a different profile from green propolis.

Bees are the link between plant and hive: they collect these resins and transform them, so the botanical fingerprint of the region ends up in the propolis. Japan, the largest importer of Brazilian green propolis, has driven decades of research on artepillin C and standardization — which is why Brazilian propolis is graded by its origin and its content of marker compounds.

Field of alecrim-do-campo (Baccharis dracunculifolia) in bloom with bees
Alecrim-do-campo (Baccharis dracunculifolia) in bloom — the plant behind green propolis.

What it is studied for

Propolis topics

Propolis and Immune Health

Propolis is one of the most popular bee products for immune support. Its flavonoids and phenolic compounds are studied for the way they interact with the body's immune cells, and human research on Brazilian green propolis has looked at how daily intake supports a healthy immune response. Propolis Health softgels are formulated with 1000mg of green propolis extract per daily dose for this purpose.

Propolis and a Healthy Inflammatory Response

Many of the compounds in propolis — artepillin C, caffeic acid derivatives and flavonoids — are studied for their role in supporting a healthy inflammatory response and helping the body manage oxidative stress. This is one of the most active areas of propolis research and part of why it has been used across cultures for so long.

Antioxidant Propolis

Propolis is rich in antioxidants. Its flavonoids and phenolic acids help neutralize free radicals and support the body's own antioxidant defenses, which is how they help protect cells from everyday oxidative stress. Green propolis standardized for artepillin C is especially valued for this antioxidant profile.

Propolis and Oral Health

Propolis has a long tradition in oral care and appears in many toothpastes, mouth rinses and lozenges. Studies on propolis extracts in oral-care products have looked at their role in supporting healthy gums and a clean mouth environment. Our extracts are taken orally as a supplement; if you want propolis for oral care, look for a product designed for that use.

Questions we hear most often

Frequently asked questions

What is propolis?

Propolis is a natural resin that honeybees produce from the buds, bark and sap of plants, blended with beeswax and bee enzymes. Bees use it to seal and line the hive and keep the colony environment clean.

As a dietary supplement, propolis is valued for its flavonoids and phenolic compounds, which support the body's antioxidant defenses and immune health.

Are all types of propolis the same?

No. Propolis varies with the plants the bees collect from and with the region. Brazilian green propolis (from Baccharis dracunculifolia) and Brazilian red propolis (from Dalbergia ecastaphyllum) are two of the best-known types, each with its own chemical profile and marker compounds.

What is Green propolis?

Green propolis is produced by bees that collect resin from alecrim-do-campo (Baccharis dracunculifolia), a shrub native to southeastern Brazil. It is rich in phenolic compounds and flavonoids, and its marker compound is artepillin C — the reason authentic green propolis is graded by origin and standardized extract content.

Does propolis support the immune system?

Yes — supporting immune health is the main reason people take propolis, and it is what most of our customers use it for. Its flavonoids and phenolic compounds are studied for how they support a healthy immune response. Propolis is a dietary supplement, not a medicine: it supports the body's normal function rather than treating any condition.

Can propolis improve oral health?

Propolis is a common ingredient in toothpastes, mouth rinses and lozenges, and studies on those products have looked at how propolis extracts support healthy gums and a clean mouth. Our products are oral supplements taken by mouth; for oral-care use, choose a product designed for that purpose and keep your regular dental routine.

What is the best time to consume bee propolis?

Propolis can be taken at any time of day. Many people take it in the morning with breakfast to build a daily habit; others prefer the evening. What matters most is consistency — taking it every day as directed on the label.

Can everyone take bee propolis?

Most adults can take propolis. Do not take it if you are allergic to bees, bee products or pollen. If you are pregnant, breastfeeding, taking medication or managing a health condition, talk to your healthcare provider before starting any supplement.

What should I look for when buying bee propolis supplements?

Look for the origin (Brazilian green or red propolis), the botanical source, the extract concentration and whether the product states its dry-extract or marker-compound content. Prefer brands that explain how and where the propolis is produced and that avoid artificial additives. Propolis Health products state their origin, extract percentage and daily dose on the label.

Is propolis a cold or flu remedy?

No. Propolis is a dietary supplement and is not intended to treat, prevent or cure colds, flu or any illness. What it can do is support your immune health as part of a daily routine, especially during the colder months. If you have symptoms of an infection, see a healthcare professional.

Can bee propolis help with specific conditions like allergies or colds?

No — propolis does not treat or prevent allergies or colds. It is taken to support immune health and a healthy inflammatory response, which is why many people take it year-round, especially when the seasons change. If you are allergic to bee products, do not take propolis.

What are the main active compounds in propolis?

Researchers have identified more than 300 compounds in propolis, and the count keeps rising. The main groups are:

• Flavonoids such as pinocembrin, chrysin, galangin and quercetin — key antioxidant compounds.

• Phenolic acids and esters such as caffeic acid, p-coumaric acid and CAPE, which support the body's antioxidant defenses.

• Prenylated phenolics such as artepillin C and baccharin, the markers of Brazilian green propolis.

• Isoflavonoids such as formononetin and vestitol, characteristic of Brazilian red propolis.

• Terpenes, essential oils and small amounts of vitamins and minerals.

What are the potential side effects or allergic reactions associated with propolis?

Propolis is well tolerated by most people, but it can cause allergic reactions — skin rash, itching or breathing discomfort — especially in people allergic to bees, bee products or pollen. Mild digestive discomfort is occasionally reported.

If you take anticoagulant medication or have a medical condition, talk to your healthcare provider before using propolis. Stop and seek advice if you notice any reaction.

How does propolis compare to other bee products like honey and royal jelly in terms of health benefits?

• Propolis is the hive's protective resin, rich in flavonoids and phenolic compounds; it is taken to support immune health and antioxidant defenses.

• Honey is mainly a natural sweetener and energy source, with some antioxidants.

• Royal jelly is the food of the queen bee, rich in proteins, B vitamins and the fatty acid 10-HDA; it is taken to support energy and vitality.

They are complementary rather than interchangeable: many of our customers combine propolis and royal jelly.

What is Red propolis?

Red propolis is produced by bees that collect the reddish resin of Dalbergia ecastaphyllum, a plant of the mangroves along the coast of northeastern Brazil (a related red propolis is also found in Cuba). It is rich in isoflavonoids such as formononetin and vestitol and is valued for its antioxidant profile.

What are the differences between Green and Red propolis?

They come from different plants and have different chemistry. Green propolis (from Baccharis dracunculifolia) is rich in artepillin C and other prenylated phenolics; red propolis (from Dalbergia ecastaphyllum) is rich in isoflavonoids. Both support antioxidant defenses and immune health; many people choose by preference or alternate between them.

What are the health benefits of bee propolis?

Propolis is taken to support immune health, the body's antioxidant defenses and a healthy inflammatory response. It also has a long tradition in oral care and skin care products. These are structure-and-function benefits of a dietary supplement — propolis is not intended to diagnose, treat, cure or prevent any disease.

Does propolis support a healthy inflammatory response?

Compounds in propolis — including artepillin C, caffeic acid derivatives and flavonoids — are studied for their role in supporting a healthy inflammatory response and helping the body manage oxidative stress. This is one of the most researched aspects of propolis. It does not replace medical treatment for inflammatory conditions.

How should bee propolis be consumed?

Propolis is available as softgel capsules, alcohol-free glycolic liquid extract and the classic alcohol-based tincture. Capsules are the most convenient; liquid extracts are taken in drops, alone or in water. Choose the form that fits your routine and follow the directions on the label.

How much bee propolis should I take daily?

Propolis Health softgels: 2 capsules a day, which delivers 1000mg of green propolis extract. Propolis Health liquid extracts: 40 drops a day, alone or in water. Other brands vary by concentration, so always follow the directions on the label, and ask your healthcare provider if you have a health condition or take medication.

How should bee propolis supplements be stored?

Keep propolis supplements in a cool, dry place away from direct sunlight. Keep liquid extracts tightly closed to preserve the extract and avoid contamination, and keep all supplements out of reach of children.

Can bee propolis be used on the skin?

Propolis has a long tradition in skin care and appears in many creams, balms and ointments. Our products are oral dietary supplements and are not formulated for skin application; if you want propolis for the skin, choose a topical product designed for that use.

Can bee propolis help with allergies?

No — propolis is not a treatment for allergies. It is taken to support immune health and a healthy inflammatory response, and some people make it part of their routine when the seasons change. Important: if you are allergic to bees, bee products or pollen, do not take propolis.

What forms of bee propolis are available (e.g., capsules, tinctures, creams)?

Propolis comes in several forms:

• Liquid extracts and tinctures: drops taken by mouth or added to water. Glycolic extracts are alcohol-free; tinctures use an alcohol base.

• Capsules and softgels: convenient, no taste, with a fixed daily dose.

• Creams, balms and oral-care products: for external or oral use, made by specialized brands.

Propolis Health offers softgels, an alcohol-free glycolic extract and a classic tincture.

How is propolis harvested and processed for human use?

Beekeepers collect propolis with screens or traps placed in the hive, or by scraping it from the frames. The raw resin is cleaned, then extracted — with alcohol, propylene glycol or water — to concentrate its active compounds. Standardization (for example, a minimum dry-extract or artepillin C content) is what keeps quality consistent from one harvest to the next, since composition varies with the plants and the season.

Can propolis be used in children, and what are the recommended dosages?

Our products are formulated for adults. Children's needs are different, and propolis can cause allergic reactions, so we recommend asking a pediatrician before giving propolis to a child and using only products formulated for children.

What scientific studies support the health claims associated with propolis?

Propolis is one of the most studied bee products. A 2021 randomized trial in 133 adults (Journal of the Science of Food and Agriculture) found that artepillin C is absorbed and detectable in blood after daily intake of Brazilian green propolis, while it was absent in the placebo group. Published research also covers:

• The antioxidant compounds of propolis and how they support the body's antioxidant defenses.

• Its role in supporting a healthy immune response, including human studies with Brazilian green propolis.

• Its role in supporting a healthy inflammatory response.

Most of this research is laboratory or early clinical work, and results should not be read as proof that propolis treats or prevents any disease. As a dietary supplement, propolis supports normal body functions.

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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.